Can I do B2B differently per region?

Yes — Adobe Commerce B2B (companies, quote workflow, requisition lists, customer-specific pricing, Net-30 / Net-60 payment terms) is scoped per website. So you can run B2C in the US, B2B in DE, and a hybrid B2B+B2C in the UK off the same backend. Each region can have its own sales reps, quote approval flow, payment terms and ERP integration. Salesforce / HubSpot / NetSuite integrations can also route per region. (Note: B2B requires Adobe Commerce, not Open Source.)