B2B pharmacy + clinic supply on the same Magento as DTC?

Yes, common pattern at $25M+ pharma. One Magento instance, two segregated pricing + access surfaces:

• DTC (consumer) store view — OTC + supplements + Rx (with prescription validation flow), retail pricing, card-only checkout.
• B2B pharmacy / clinic / hospital store view — full catalog including controlled substances, NDC contract pricing, GPO-aware pricing (Premier / Vizient / HealthTrust contracts auto-applied per buyer’s GPO membership), Net-30 / Net-60 invoicing, ACH / wire / EDI payment.

B2B-specific Magento features:

• Buyer onboarding: DEA registration validation (DEA Active Registrants API), state board license, business tax ID (EIN), Wholesaler Distributor Number (WDN where applicable), GPO membership upload. Manual approval queue for compliance review.
• Tier pricing: NDC-level contract pricing per buyer-account, fallback to GPO contract, fallback to list price. ~50% of pharma B2B revenue runs on contract pricing — getting this wrong = revenue leak or buyer dispute.
• EDI integration: 850 (PO), 855 (PO ack), 856 (ASN), 810 (invoice), 820 (payment), 824 (correction). Hospital procurement systems (Workday, Lawson, Oracle Cloud HCM) consume these natively. Magento-to-EDI bridge via SPS Commerce / TrueCommerce / Cleo.
• 340B program compliance for federally-funded entities — separate price column, quarterly HRSA reconciliation report.

Adobe Commerce native B2B Companies module covers most of this; Open Source needs Aheadworks B2B Suite + Amasty Company Accounts + a custom NDC-pricing module. I default to Adobe Commerce at this scale — the license fee ($30k–$200k/yr) pays back via the saved dev time + native quote workflow.