Multi-region distribution (US + EU + UK), Magento native?

Yes, via Magento Multi-Source Inventory (MSI), native since 2.3.0. Architecture:

• Define sources (warehouses) per region: us_east_warehouse, us_west_warehouse, eu_de_warehouse, eu_nl_warehouse, uk_warehouse.
• Define stocks (shopping experiences) per region: US stock aggregates US-east + US-west sources; EU stock aggregates DE + NL + FR + IT sources; UK stock is UK-only post-Brexit.
• Customer geo-routes to a stock via store view; stock aggregates inventory from its sources; cart shows accurate availability.
• Source-selection algorithms decide which warehouse fulfills each line item (priority-based, distance-based, or stock-balance-based).

Multi-region pricing + currency: separate store views per region. US in USD with tax-excluded prices; EU in EUR with VAT-included; UK in GBP with VAT-included. Same SKUs, different price visibility, different checkout (Klarna in EU, Affirm in US, Clearpay in UK).

Multi-region freight: ShipperHQ regional rate cards per stock. US stock uses FedEx Freight / XPO / R+L / Old Dominion; EU stock uses DPD / DHL Freight / GLS; UK stock uses Tuffnells / Palletline / Palletways. Tax: Avalara or TaxJar for US sales tax; VAT handled natively in EU + UK store views.

Brexit gotcha: UK stock must be physically separated from EU stock for VAT + customs. Don’t share inventory across the channel.